山东医药2011，Vol.51Issue(25)：6-8,3.
大剂量阿托伐他汀对急性脑梗死患者血清炎性因子的影响
Influence of high-dose atorvastatin on inflammatory factors in patients with acute cerebral infarction
摘要
Abstract
Objective To observe the influence of high-dose atorvastatin treatment on inflammatory factors in patients with acute cerebral infarction (ACI). Methods According to the results of carotid artery ultrasound, 136 cases of patients with ACI were divided into carotid vulnerable plaque group and carotid stable plaque group in each of which had 68 cases.34 cases were both randomly selected in two groups and given a small dose ( low-dose gtoup) and high dose atorvastatin (high-dose group) treatment. Blood lipoprotein, high sensitivity C-reactive protein (hs-CRP), interleukin-17 (IL-17) and marix metalloproteinase-9 (MMP-9) were detected before treatment and after treatment for 2 weeks. Results After treatment, levels of LDL-C, TG, TC, hs-CRP, IL-17 and MMP-9 were significantly decreased in both groups (P ＜0. 01 ),which in high-dose group were lower than those in low-dose group (P ＜ 0.05 or ＜ 0.01 ). Conclusion High-dose atorvastatin could rapidly reduce serum inflammatory factors in patients with ACI, thus might have the stronger.anti-inflammation function and improve the stability of vulnerable plaque.关键词
脑梗死,急性/阿托伐他汀/C反应蛋白质/白细胞介素-17/明胶酶类Key words
cerebral infarction, acute/ atorvastatin/ C-reactive protein/ interleukin-17/ gelatinnse分类
医药卫生引用本文复制引用
李强..大剂量阿托伐他汀对急性脑梗死患者血清炎性因子的影响[J].山东医药,2011,51(25):6-8,3.基金项目
武汉市卫生局科研资助项目(WX10C23). （WX10C23）
