安徽农业科学2009，Vol.37Issue(32)：15851-15852,15862,3.
牛心朴子总生物碱对小鼠亚急性毒性试验的病理组织学观察
Histopathologic Observation of Cynanchum komarovii Total Alkaloid to Subacute Toxicity Test of Mice
摘要
Abstract
[Objective] The paper aimed to study the effect of Cynanchum komarovii total alkaloid to subacute toxicity test of mice. [Method]32 mice were divided into a control group infused 0.5 ml/d distilled water, and three experimental groups (low, middle, high dose group) given medicine with the daily dose of 12, 24, 48 mg/kg bw in 30 days. After the subacute toxicity test, histopathologic sections of organs were observed. [Result] The result showed that no evident poisoning symptom and no animal death after the test. Results demonstrated that the mice of low dosage group and middle dose group had no obvious cytopathic effect; and the mice of high dose group emerged obvious CPE in main visceras. [Conclusion] Under the experimental conditions of the subacute toxicity test in mice, a certain concentration had varying degrees toxic effect on the heart, liver, stomach, spleen, lung kidney and ovary.关键词
牛心朴子/总生物碱/亚急性毒性Key words
Cynanchum komarovii/ Alkaloid/ Subacute Toxicity分类
农业科技引用本文复制引用
汪仁莉,何生虎,张珠明..牛心朴子总生物碱对小鼠亚急性毒性试验的病理组织学观察[J].安徽农业科学,2009,37(32):15851-15852,15862,3.
