北京中医药大学学报2009，Vol.32Issue(9)：633-635,640,4.
丹参酚酸肠吸收特性研究
Features of intestinal absorption of salvianolic acid
陈贤春 1吴清 2李冀湘 1石红欣 3张玲4
作者信息
- 1. 中国中医科学院广安门医院,北京,100053
- 2. 北京中医药大学中药学院
- 3. 北京采瑞医药科技有限公司
- 4. 山东中医药大学药学院
- 折叠
摘要
Abstract
Objection To study the intestinal absorptive features of salvianolic acid taking salvianic acid A sodium and protocatechuic aldehyde as the indexes. Methods The method of intestinal absorption was applied in vivo in rats for establishing a quantitative determination of salvianic acid A sodium and protocatechuic aldehyde. The influences of different absorptive segments of intestines, drug concentrations and pH conditions on the intestinal absorptive volume of salvianic acid A sodium and protocatechuic aldehyde were observed, and the parameter of absorptive dynamics was studied. Results There was no specified absorptive segments of intestines. The absorptive volume had a good linear relationship in the range of test concentration without saturation. The value of pH had no influence on intestinal absorption of salvianic acid A sodium, but had on protocatechuic aldehyde. The absorptive rate constant of salvianic acid A sodium (Ka) was 0.3996 h~(-1) and T_(1/2) was 1.734 h, and that of protocatechuic aldehyde, 0.401 9 h~(-1) and T_(1/2), 1.724 h. Conclusion Salvianolic acid can be absorbed well in the intestines, and the mechanism is that the absorption is in a passive diffusion way.关键词
丹参酚酸/丹参素钠/原儿茶醛/肠吸收特性Key words
salvianolic acid/ salvianic acid A sodium/ protocatechuic aldehyde/ intestinal absorptive features分类
医药卫生引用本文复制引用
陈贤春,吴清,李冀湘,石红欣,张玲..丹参酚酸肠吸收特性研究[J].北京中医药大学学报,2009,32(9):633-635,640,4.
