波谱学杂志2009，Vol.26Issue(4)：485-491,7.
糖尿病大鼠视神经病变方向性扩散加权MRI表现
Early Pathological Changes in the Optic Nerves of STZ-Treated Diabetic Rats Revealed by Directional Diffusion-Weighted MRI
摘要
Abstract
Type-I diabetes was induced in rats by a single injection of streptozotocin (STZ). Directional diffusion-weighted imaging on the optic nerves were performed one month later to monitor the early optic neuropathy (e.g., axonal injury and myelin sheaths damage) induced by diabetes. Water diffusivities parallel and perpendicular to the axonal tracts were measured by apparent diffusion coefficients ADC_∥ and ADC_⊥, respectively. Compared to the control animals, the STZ-treated animals showed a trend of reduced ADC_⊥ in bilateral optic nerves, but less consistent changes in ADC_∥.关键词
扩散磁共振成像(MRI)/视神经/STZ/糖尿病Key words
MRI/ diffusion/ optic nerves/ streptozotocin/ diabetes分类
医药卫生引用本文复制引用
高丽凤,黄明明,雷皓..糖尿病大鼠视神经病变方向性扩散加权MRI表现[J].波谱学杂志,2009,26(4):485-491,7.基金项目
国家自然科学基金资助项目(30870674). （30870674）
