中德临床肿瘤学杂志（英文版）2009，Vol.8Issue(11)：665-668,4.DOI:10.1007/s10330-009-0157-9
乳腺癌钼靶X线表现特征(118例分析)
Clinicopathological significance and relations of Caspase-3 expression, cell proliferation and apoptosis in gastric cancer and the precancerous lesions
摘要
Abstract
Objective: we investigated the relationship between the expression of Caspase-3. cell proiferation and apoptosis in gastric cancer and their precancerous lesions, to explore the tumorigenesis of the stomach mucosa. Methods: Caspase-3 expression in 13 normal gastric mucosa, 6 chronic atrophic gastritis (CAG), 31 intestinal metaplasia (IM), 114 dysplasia (DYS) and 20 gastric carcinomas were investigated immunohistochemically. Cell proliferation was evaluated with anti-Ki-67immunostaining and apoptosis was evaluated using DNA fragmentation in situ by TdT-mediated dUTP biotin nick end label-ing (TUNEL) method. Results: Caspase-3 mild-moderately positive expression was observed in most of normal superficial epithelia, its positively polar distribution in normal mucosa, CAG, IM, DYS and gastric carcinomas changed as seen in TU-NEL, and so did the positive rate. Caspase-3 protein expression showed significantly positive correlation with the number of apoptotic cells labeled with TUNEL (correlation coefficient r=0.94; P < 0.01). Ki-67 expression showed a negative but not significant correlation trend with Caspase-3 (correlation coefficient r=-0.23; P> 0.05). Conclusion: Caspase-3 protein expression was up-regulated from CAG to IM and mild-moderate atypical dysplasia, but down-regulated in severe dysplasia and gastric carcinoma, indicating that inactivity or reduced expression of Caspase-3 is closely correlated with carcinogenesis of the stomach mucosa.关键词
precancerous lesions/ gastric cancer/ Caspases-3/ apoptosisKey words
precancerous lesions/ gastric cancer/ Caspases-3/ apoptosis分类
医药卫生引用本文复制引用
XiaoBin Hu,Jing Zhao,Lin Yang,Yan Xin..乳腺癌钼靶X线表现特征(118例分析)[J].中德临床肿瘤学杂志（英文版）,2009,8(11):665-668,4.基金项目
Supported by grants from the National Natural Science Foundation of China (No. 30070845, 30271607, 30600286) （No. 30070845, 30271607, 30600286）
Climbing Scholars of the Universities in Liaoning Province (2009-2011). （2009-2011）
