南方医科大学学报2009，Vol.29Issue(10)：1965-1968,4.
肝纤维化MR弥散加权成像与病理的对照研究
A comparative study of diffusion-weighted magnetic resonance imaging and pathological findings of liver fibrosis in rabbits
摘要
Abstract
Objective To investigate the alteration of apparent diffusion coefficient (ADC) in diffusion-weighted MR imaging (MR-DWI) of liver fibrosis and its pathological basis in rabbits. Methods Five rabbits in the control group and 22 with experimental liver fibrosis induced by transperitoneal injection of carbon tetrachloride (CCl4) were examined with MR-DWI. Diffusion-weighted SE EPI sequence with a relatively high b factor (b=600 s/mm~2) was used to measure the ADC. The mean values of ADC were compared among the rabbits in different stages of liver fibrosis and analyzed in relation to the pathological findings. Results The mean ADC value decreased significantly with increased severity of liver fibrosis (P<0.05). Pathologically, the amount and extension of fibrotic matrix increased, and the hepatic necroinflammation worsened with the progression of the liver fibrosis. Conclusion The ADC value decreases with the progression of liver fibrosis possibly as the result of water diffusion limitation due to increased fibrous tissue in the liver and abnormal water diffusion within the intracellular and extracellular spaces.关键词
肝纤维化/磁共振成像/弥散加权成像/显微镜检查/电子/动物/实验Key words
liver fibrosis/ magnetic resonance imaging/ diffusion weighted imaging/ microscopy/ electron/ animals/ experimental分类
医药卫生引用本文复制引用
王秋实,邹艳,刘辉,刘再毅,梁长虹..肝纤维化MR弥散加权成像与病理的对照研究[J].南方医科大学学报,2009,29(10):1965-1968,4.基金项目
国家自然科学基金(30800269) （30800269）
广东省科技计划资助项目(2005810401040) （2005810401040）
