南方医科大学学报2009，Vol.29Issue(10)：1973-1976,1981,5.
成都地区汉族人群17个Y短串联重复序列基因座遗传多态性分析
Analysis of the genetic polymorphism of 17 Y-chromosomal short tandem repeat loci in the Han population in Chengdu
摘要
Abstract
Objective To obtain the population genetic data of 17 Y-chromosomal short tandem repeat (Y-STR) in the Han population in Chengdu of Sichuan Province. Methods The 17 Y-STR loci were amplified from the blood samples of 111 unrelated Chengdu Han individuals using the AmpF1STR~(R)Yfiler~(TM) system. The PCR products were genotyped with an ABI 3130 genetic analyzer. Results In the loci of in DYS456, DYS389I, DYS390, DYS389II, DYS458, DYS19, DYS385a/b, DYS393, DYS391, DYS439, DYS635, DYS392, Y-GATA-H4, DYS437, DYS438, and DYS448, 3 to 8 alleles were detected in the Han population in Chengdu, and 36 alleles were detected in the locus DYS385a/b, with the minimal gene diversity (GD) value of 0.3970 (DYS391) and maximal value of 0.9561 (DYS385a/b). The DNA samples of 16 women and 7 different species of animals were amplified, but no specific products were found for the 17 Y-STR loci. No mutations of the 17 Y-STR alleles were observed in 20 father-son pairs as confirmed by autosomal STR analysis. Conclusion The 17 Y-STR loci are highly polymorphic and are suitable for personal identification, paternity testing, population genetics and anthropology studies.关键词
Y染色体/短串联重复序列/遗传多态性/单倍型/成都汉族人Key words
Y chromosome/ short tandem repeats/ genetic polymorphism/ haplotype/ Han nationality分类
生物科学引用本文复制引用
宋兴勃,范红,应斌武,陆小军,王军,叶远馨..成都地区汉族人群17个Y短串联重复序列基因座遗传多态性分析[J].南方医科大学学报,2009,29(10):1973-1976,1981,5.基金项目
国家自然科学基金(30871117)Supported by National Natural Science Foundation of China(30871117) （30871117）
