南方医科大学学报2009，Vol.29Issue(10)：2067-2069,3.
早期鼻咽癌血管内皮细胞生长因子表达与肿瘤组织~(18)F-FDG摄取的关系
Relationship between fluorodeoxyglucose uptake and vascular endothelial growth factor in early-stage nasophygeal carcinoma
范义湘 1石卫民 2黎静 3尹吉林 4杨传红 5高梅菊 1吴继珍 1刘青竹 1李科斌1
作者信息
- 1. 广东省第二人民医院核医学科,广东,广州,510317
- 2. 广东省第二人民医院肿瘤一科,广东,广州,510317
- 3. 广州军区广州总医院肿瘤科,广东广州,510010
- 4. 广州军区广州总医院核医学科,广东广州,510010
- 5. 广州军区广州总医院医学实验科,广东广州,510010
- 折叠
摘要
Abstract
Objective To study the overexpression of vascular endothelial growth factor (VEGF) and fluorine-18 fluorodeoxyglucose (FDG) uptake in early-stage nasopharyngeal carcinoma (NPC) and evaluate their relationship. Methods FDG positron emission tomography (PET) was performed in forty patients with stage I and stage II NPC. The maximum and mean standard uptake values (SUV_(max) and SUV_(mean) ,respectively) were measured in each patient, and the expression of VEGF was measured on paraffin sections using immunohistochemistry. Results The FDG uptake in the patients were 9.45±1.87 (SUV_(max)) and 6.04±1.09 (SUV_(mean)), 8.95±1.91 (SUV_(max)) and 6.04±1.09 (SUV_(mean)) in stage I patients, and 11.55±1.70 (SUV_(max)) and 7.98±1.1 (SUV_(mean)) in stage II patients. The FDG uptake of stage II patients was higher than that of stage I patients. The FDG uptake of non-keratinizing differentiated carcinoma was 9.74±1.82 (SUV_(max)) and 6.82±1.23 (SUV_(mean)) and 10.44±2.16 (SUV_(max)) and 6.68±1.35 (SUV_(mean)) in non-keratinizing undifferentiated carcinoma, showing no significant differences between them (SUV_(max): t=1.230, P>0.05; SUV_(mean): t=0.346, P>0.05). The VEGF-positive cells were 60.80% in the tumor. A correlation between VEGF expression and FDG uptake in he tumor was noted (r=0.460, P=0.03). Conclusion VEGF overexpression is correlated to FDG uptake in patients with early-stage NPC. The SUV value reflects the glucose metabolism of NPC, and also shows the degree of oxygen insufficiency in the tumor tissue.关键词
鼻咽肿瘤/血管内皮生长因子/FDG/放射性示踪剂/体层摄影术/发射型计算机Key words
nasopharyngeal neoplasms/ vascular endothelial growth factor/ fluorine-18 fluorodeoxyglucose/ radioactive tracers/ tomography/ emission-computed分类
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范义湘,石卫民,黎静,尹吉林,杨传红,高梅菊,吴继珍,刘青竹,李科斌..早期鼻咽癌血管内皮细胞生长因子表达与肿瘤组织~(18)F-FDG摄取的关系[J].南方医科大学学报,2009,29(10):2067-2069,3.
