南方医科大学学报2009，Vol.29Issue(11)：2319-2320,2323,3.
多西他赛与奥沙利铂联合治疗复发性上皮性卵巢癌疗效评价
Therapeutic effect of docetaxel combined with oxaliplatin for treatment of recurrent epithelial ovarian cancer
王健 1韩娜 2王海莉 2张中冕 2樊青霞1
作者信息
- 1. 郑州大学第一附属医院肿瘤科,河南,郑州,450052
- 2. 郑州大学第二附属医院肿瘤科,河南,郑州,450052
- 折叠
摘要
Abstract
Objective To evaluate the efficacy and safety of docetaxel (Taxotere) (DTX) and oxaliplatin (OXA) for treatment of recurrent epithelial ovarian cancer. Methods Thirty-six patients with histologically confirmed recurrent epithelial ovarian cancer received chemotherapy with DTX and OXA. DTX at the dose of 75 mg/m2 was administered on day 1 by intravenous infusion in 60 min, followed by OXA at 100 mg/m~2 given by a 2 h infusion. The chemotherapy cycles were repeated every 21 days, and the patients received at least 2 cycles. Results All the patients were available for response evaluation, among whom 3 (8.3%) showed complete responses and 17 (47.2%) showed partial responses, with an overall response rate of 55.6%. The main adverse effects included hematological toxicities and peripheral neuropathy. Conclusion Combination of DTX and OXA produces good therapeutic effect with tolerable toxicity profile for treatment of recurrent epithelial ovarian cancer.关键词
复发性上皮性卵巢癌/药物治疗/多西他赛/奥沙利铂Key words
recurrent epithelial ovarian cancer/drug therapy/ docetaxel/ oxaliplatin分类
医药卫生引用本文复制引用
王健,韩娜,王海莉,张中冕,樊青霞..多西他赛与奥沙利铂联合治疗复发性上皮性卵巢癌疗效评价[J].南方医科大学学报,2009,29(11):2319-2320,2323,3.
