南方医科大学学报2009，Vol.29Issue(11)：2324-2326,2328,4.
Tiam1在乳腺癌组织中的表达及临床意义
Expression of Tiam1 in breast carcinomas and its clinical significance
吴元清 1彭刚1
作者信息
- 1. 湘潭职业技术学院护理系,湖南,湘潭,411100
- 折叠
摘要
Abstract
Objective To investigate the expression of T lymphoma invasion and metastasis inducing factor 1 (Tiam1) in breast carcinomas, and explore its association with the clinicopathological features of breast carcinoma. Methods Immunohistochemistry was used to detect Tiam1 expression in normal breast tissue and 126 breast carcinoma tissues, and the expression levels of Tiam1 mRNA and protein were detected by reverse transcriptase polymerase chain reaction (RT-PCR) and Western blotting, respectively. Results The expression of Tiam1 was significantly higher in breast carcinomas than in normal breast tissue (P<0.05). Tiam1 expression was not correlated to the age of the patients or the histological type (P>0.05), but to lymph node metastasis and clinical stages of the tumor (P<0.01). Tiam1 mRNA and protein expressions were stronger in breast carcinoma cell line MDA-MB-435 with high metastatic potential than in breast carcinoma cell line MCF-7. Conclusion Tiam1 is closely related to the metastasis of breast carcinoma, and may play an important role in promoting metastasis of breast carcinoma.关键词
乳腺肿瘤/T淋巴瘤侵袭转移诱导因子1/肿瘤转移Key words
breast neoplasms/ T lymphoma invasion and metastasis inducing factor 1/ neoplasm metastasis分类
医药卫生引用本文复制引用
吴元清,彭刚..Tiam1在乳腺癌组织中的表达及临床意义[J].南方医科大学学报,2009,29(11):2324-2326,2328,4.
