辐射防护2009，Vol.29Issue(6)：385-389,421,6.
辐射致人正常肝细胞蛋白质组电泳图谱的改变
STUDY OF DIFFERENTIAL PROTEIN EXPRESSION IN HUMAN NORMAL LIVER CELLS EXPOSED TO RADIATION
王放 1左雅慧 1王小莉 1郭华平 1李建国 1王仲文2
作者信息
- 1. 中国辐射防护研究院,太原,030006
- 2. 中国原子能科学研究院,北京,102413
- 折叠
摘要
Abstract
The study analyzed the proteinaceous change of human liver cells at 4 hours after radiation of 0.5 and 2 Gy γ-ray by proteomics.The results showed that compared with control group,4 hours after radiation,the protein points of different expression in the handled group irradiated by 0.5 Gy were 146.Among the total,up-expressed protein points were 67 and down-expressed ones were 79.On the other hand,the protein points of different expression in the handled group irradiated by 2 Gy were 127,and among the total,up-expressed ones were 83 and down-expressed ones were 44.The protein points of common different expression in the handled groups irradiated by 0.5 Gy and 2 Gy were 56,and among the total,up-expressed ones were 39 and down-expressed were 17.The results of SELDI showed that the protein points of common different expression are cytoskeletal protein,signal transducer and metabolism-associated protein et al.关键词
辐射/人肝细胞/蛋白质组/差异表达蛋白Key words
Radiation/Human Liver Cells/Proteome/Differential Expression Protein分类
数理科学引用本文复制引用
王放,左雅慧,王小莉,郭华平,李建国,王仲文..辐射致人正常肝细胞蛋白质组电泳图谱的改变[J].辐射防护,2009,29(6):385-389,421,6.
