分析化学2009，Vol.37Issue(11)：1566-1571,6.
透皮无创血糖监测技术中的关键电化学问题研究
Study of Key Electrochemical Problems in Transdermal Noninvasive Glucose Monitoring
摘要
Abstract
Several key problems were analysed for the transdermal noninvasive glucose monitoring. A modified calibration equation was proposed for the high-sensitivity glucose biosensor due to its narrow linear range. The new equation has increased the sensors' linear range by 20 times. A new diffuse model was constructed for the electrode system of glucose sensor,aiming at the unique "finite space" electrochemical problem in trans-dermal technique. In addition,electrode masks were utilized to solve the problem of electrode loss in longtime glucose monitoring. In animal in-vivo experiments,70.1 % of the noninvasive glucose data points were clinically accurate,while the remains were clinically acceptable. All solutions mentioned above were based on both theoretical analysis and experimental validation,promoting the realization and optimization of transdermal noninvasive glucose monitoring techniques.关键词
透皮取样技术/葡萄糖传感器/有限空间/电极损耗/电极掩膜Key words
Transdermal sampling techniques/glucose sensor/finite space/electrode loss/electrode mask分类
化学化工引用本文复制引用
杨庆德,刘红敏,刘春秀,贺银增,田青,蔡新霞..透皮无创血糖监测技术中的关键电化学问题研究[J].分析化学,2009,37(11):1566-1571,6.基金项目
本文系国家863计划项目(No.2007AA042105)、国家自然科学基金项目(No.60801032)、中科院创新项目(No.KGCX2-YW-111-2)和中科院电子所创新项目(Nos.08SQCX-9251,07QNCX-9240)资助 （No.2007AA042105）
