高等学校化学学报2009，Vol.30Issue(11)：2199-2203,5.
透明质酸三糖模拟物的高效合成
Highly Efficient Synthesis of Two Hyaluronan Trisaccharide Analogues for Potential Hyaluronic Acid Synthases Inhibitors
摘要
Abstract
The syntheses of two hyaluronan trisaccharide analogues, naphthyl 0-(3-methoxy-B-D-glucopy-ranosyluronic acid)-(1,3)-O-(2-acetamido-2-deoxy-B-D-glucopyranosyl)-(1,4)-0-B-D-glucopyranosyluronic acid and naphthyl O-(3-methoxy-2-acetamido-2-deoxy-B-D-glucopyranosyl)-(1,4)-O-(B-D-glucopyranosylu-ronic acid)-(1,3 )-O-2-acetamido-2-deoxy-B-D-glucopyranoside, were described. Construction of the target molecules was achieved through a combination of BF_3·Et_2O/toluene system and trichloroacetimidate glycosyia-tion methodology. This is the first report on the synthesis of the 3-methoxyl derivatives, which represent the smallest fragments that incorporate all the structural features of polymeric hyaluronan and can be used for potential hyaluronic acid synthases inhibitors.关键词
透明质酸/透明质酸合成酶/抑制剂/2-萘基甲基(NAP)Key words
Hyaluronan/ Hyaluronic acid synthase/ Inhibitor/ 2-Naphthylmethyl(NAP)分类
化学化工引用本文复制引用
魏国华,杜宇国,Khushi L. Matta..透明质酸三糖模拟物的高效合成[J].高等学校化学学报,2009,30(11):2199-2203,5.基金项目
国家自然科学基金(批准号: 30701043)资助. （批准号: 30701043）
