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国际口腔科学杂志（英文版）2009，Vol.1Issue(1)：16-25,10.
Effect of Same-dose Single or Dual Field Irradiation on Damage to Miniature Pig Parotid Glands
Effect of Same-dose Single or Dual Field Irradiation on Damage to Miniature Pig Parotid Glands
摘要
Abstract
Aim To evaluate the effect of single or dual field irradiation (IR) with the same dose on damage to miniature pig parotid glands. Methodology Sixteen miniature pigs were divided into two IR groups (n=6) and a control group (n=4). The irradiation groups were subjected to 20 Gy X-radiation to one parotid gland using single-field or dual-field modality by linear accelerator. The dose-volume distributions between two IR groups were compared. Saliva from parotid glands and blood were collected at 0, 4, 8 and 16 weeks after irradiation. Parotid glands were removed at 16 weeks to evaluate tissue morphology. Results The irradiation dose volume distributions were significantly different between single and dual field irradiation groups (t=4.177, P=0.002), although dose volume histogramin (DVH) indicated the equal maximal dose in parotid glands. Saliva flow rates from IR side decreased dramatically at all time points in IR groups, especially in dual field irradiation group. The radiation caused changes of white blood cell count in blood, lactate dehydrogenase and amylase in serum, calcium, potassium and amylase in saliva. Morphologically, more severe radiation damage was found in irradiated parotid glands from dual field irradiation group than that from single field irradiation group. Conclusion Data from this large animal model demonstrated that the radiation damage from the dual field irradiation was more severe than that of the single field irradiation at the same dose, suggesting that dose-volume distribution is an important factor in evaluation of the radiobiology of parotid glands.关键词
irradiation damage/ miniature pig/ parotid glandKey words
irradiation damage/ miniature pig/ parotid gland分类
口腔医学引用本文复制引用
Xing Yan,Bo Hai,Zhao-chen Shan,Chang-yu Zheng,Chun-mei Zhang,Song-lin Wang..Effect of Same-dose Single or Dual Field Irradiation on Damage to Miniature Pig Parotid Glands[J].国际口腔科学杂志（英文版）,2009,1(1):16-25,10.基金项目
This study Was supposed by the National Natural Science Foundation of China(Grant 30430690)and Beijing Major Scientific Program Grants(D0906007000091). （Grant 30430690）
