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壳聚糖-硫酸软骨素共混膜与兔角膜基质细胞相容性的研究

姚子昂 吴海歌 刘媛媛 囤景鑫

高技术通讯2009,Vol.19Issue(11):1206-1210,5.
高技术通讯2009,Vol.19Issue(11):1206-1210,5.DOI:10.3772/j.issn.1002-0470.2009.11.019

壳聚糖-硫酸软骨素共混膜与兔角膜基质细胞相容性的研究

The compatibility between chitosan-chondroitin sulfate blend membrane and rabbit keratocytes

姚子昂 1吴海歌 1刘媛媛 1囤景鑫1

作者信息

  • 1. 大连大学辽宁省生物有机化学重点实验室,大连,116622
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摘要

Abstract

In order to explore the compatibility between chitosan membrane and rabbit keratocytes , rabbit keratocytes were cultured on the surface of different chitosan-chondroitin sulfate blend membranes. The cell adhesion on blend membranes, the growth of cells, protein metabolism and cell morphology were investigated. It was found that chondroitin sulfate could improve cell-adhesion and cells proliferation on blend membranes and it also could reduce the injury to the rabbit keratocytes and accelerate the protein metabolism of rabbit keratocytes. All the results indicate that chondroitin sulfate could improve the compatibility between chitosan membrane and rabbit keratocytes and chitosan-chondroitin sulfate blend membrane had the potential as a carrier of keratocytes culture and transplant.

关键词

壳聚糖-硫酸软骨素共混膜/兔角膜基质细胞/相容性

Key words

chitosan-chondroitin sulfate blend membrane/rabbit keratocytes/compatibility

分类

信息技术与安全科学

引用本文复制引用

姚子昂,吴海歌,刘媛媛,囤景鑫..壳聚糖-硫酸软骨素共混膜与兔角膜基质细胞相容性的研究[J].高技术通讯,2009,19(11):1206-1210,5.

基金项目

国家自然科学基金(30600145)资助项目. (30600145)

高技术通讯

OA北大核心CSCDCSTPCD

1002-0470

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