医学分子生物学杂志2009，Vol.6Issue(6)：542-546,5.DOI:10.3870/j.issn.1672-8009.2009.06.016
mTOR信号通路与调节
mTOR Signaling Pathway and Regulation
摘要
Abstract
Mammalian target of rapamycin(mTOR),an atypical Ser/Thr protein kinase,can integrate extracellular signals,and phosphorylates its downstream p70S6 kinases,such as S6K1 and 4E-BP1.Phosphorylation of S6K1 and 4E-BP1 is subsequently involved in regulation of transcription and translation,thereby modulating cell growth and proliferation.Recent studies have shown that some pathologic processes can be interfered through modulating mTOR pathways.Studies on mTOR signaling may provide insights into new targets for treatment of diseases related to mTOR signaling.关键词
哺乳动物雷帕霉素靶蛋白/信号通路/调节Key words
mammalian target of rapamycin/signaling pathway/modulate分类
生物科学引用本文复制引用
陈洪菊,李晋辉,屈艺,母得志..mTOR信号通路与调节[J].医学分子生物学杂志,2009,6(6):542-546,5.基金项目
国家自然科学基金项目(No.30825039,30770748),四川省青年科技基金(No.08ZQ026-069) （No.30825039,30770748）
