医学分子生物学杂志2009，Vol.6Issue(6)：547-549,3.DOI:10.3870/j.issn.1672-8009.2009.06.017
Necroptosis的调控机制及其在组织及细胞缺血损伤中的作用和意义
Regulatory Mechanism and Important Role of Necroptosis in Tissue and Cell Ischemic Injury
摘要
Abstract
Necroptosis is different from necrosis and apoptosis and characterized by necrotic cell death morphology and activation of autophagy.Necroptosis is an active and energy consuming cell death mechanism,which is regulated by a set of signal-transduction pathways.The discovery and identification of necroptosis has initiated a new approach of research and application for cell death reversion and treatment.RIP1 kinase has been identified as a key enzyme to regulate necroptosis.Necrostatins are one kind of small molecule compounds that specifically block the execution of necroptosis by inhibiting RIP1 kinase activity.In this review,we elucidate the execution and regulation of tissue and cell necroptosis from gene level,cellular level to animal models,to provide comprehensive information and understanding of necroptosis.关键词
坏死状凋亡/RIP1/Necrostatins/组织缺血损伤Key words
Necroptosis/RIP1/Necrostatins/tissue ischemic injury分类
生物科学引用本文复制引用
于光耀,贾彩云,马远方..Necroptosis的调控机制及其在组织及细胞缺血损伤中的作用和意义[J].医学分子生物学杂志,2009,6(6):547-549,3.基金项目
河南省杰出人才创新基金(No.074200510014) （No.074200510014）
