医学分子生物学杂志2009，Vol.6Issue(6)：550-554,5.DOI:10.3870/j.issn.1672-8009.2009.06.018
中国汉族人群2型糖尿病易感性相关基因多态性
Single-Nucleotide Polymorphisms of Candidate Genes for Type 2 Diabetes in Chinese Han Population
徐佳岱 1韩晓1
作者信息
- 1. 南京医科大学生物化学与分子生物学系,南京市,210029
- 折叠
摘要
Abstract
Type 2 diabetes mellitus(T2DM)is determined by multiple gene additive effects and various environmental factors. The single-nucleotide polymorphisms(SNPs)related to T2DM candidate genes in the examined Chinese population include the genome-wide associated CDKAL1,CDKN2A/B,SLC30A8,IGF2BP2,HHEX,FTO and KCNQ1 genes,the adiponectin gene,the nuclear respiratory factor 1 gene,the glucokinase gene,and the tumor necrosis factor gene,etc. It is of great importance of exploring these susceptible genes to understand T2DM pathogenesis and improve T2DM treatment. However,few genes have been determined,due to divisive results. Therefore,further investigation needs to be undertaken.关键词
基因多态性/2型糖尿病/中国人群Key words
single-nucleotide polymorphisms（SNPs）/type 2 diabetes mellitus（T2DM）/Chinese population分类
生物科学引用本文复制引用
徐佳岱,韩晓..中国汉族人群2型糖尿病易感性相关基因多态性[J].医学分子生物学杂志,2009,6(6):550-554,5.
