核化学与放射化学2009，Vol.31Issue(4)：246-249,4.
两株人肺癌细胞摄取~(99)Tc~m-MIBI的比较
Comparison of the Uptake of ~(99)Tc~m-MIBI in Two Lung Cancer Cell Lines
摘要
Abstract
The uptake characters of ~(99)Tc~m-MIBI in two lung cancer cell lines (human small cell lung cancer H446 cells and human lung adenocarcinoma SPC-1 cells) were investigated. The uptake kinetic data show that H446 cells absorb significantly higher level of ~(99)Tc~m-MIBI comparing with SPC-1 cells. The uptake percentage of ~(99)Tc~m-MIBI in H446 cells increases time-dependently and reaches its peak value at about 120 min, and then droppes slowly. This uptake in H446 cells is positively correlated with the number of cells while negatively with the concentration of radiolabelled ~(99)Tc~m-MIBI. Furthermore, it is markedly inhibited by excessive unlabelled MIBI. However, the uptake of ~(99)Tc~m-MIBI in SPC-1 cells maintains at low levels without a visible peak during the experiment time. These results suggest that the uptake characters of ~(99)Tc~m-MIBI are different in two lung cancer cell lines, which is accordant with the clinical facts that patients with lung cancers displayed diverse ~(99)Tc~m-MIBI imaging patterns.关键词
人肺癌细胞/~(99)Tc~m-MIBI/细胞摄取Key words
human lung cancer cell lines/ ~(99)Tc~m-MIBI/ cellular uptake分类
医药卫生引用本文复制引用
俞惠新,谭成,张莉,李卫一,林秀峰,陈波,曹国宪,王正武..两株人肺癌细胞摄取~(99)Tc~m-MIBI的比较[J].核化学与放射化学,2009,31(4):246-249,4.基金项目
江苏省自然科学基金资助项目(BK2006026) （BK2006026）
无锡市自然科学基金资助项目(CK040004) （CK040004）
