四川大学学报（医学版）2009，Vol.40Issue(6)：1056-1061,6.
中国肥胖患者β_2 肾上腺素受体基因多态性的研究
Polymorphism in β_2 Adrenergic Receptor Gene in Chinese Population with Obesity
摘要
Abstract
Objective To investigate the variation of β_2 adrenergic receptor (β_2AR) gene and its association with obesity in Chinese population. Methods The allele of β_2AR gene at Argl6Gly and Gln27Glu sites were analysed with polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) in 396 people with Han nationality in Chengdu, among whom 126 had obesity. Results The allele frequencies of Arg and Gly at Argl6Gly site were 0. 571 and 0. 429 for the obese people, and 0. 559 and 0. 441 for the non-obese people, respectively. The allele frequencies of Gin and Glu at Gln27Glu site were 0. 920 and 0. 080 for the obese people, and 0. 916 and 0. 084 for the non-obese people, respectively. No significant differences were found in the genotype frequencies of the two sites between non-obese and obese people. The non-obese females and obese males with genotype Arg/Arg at Argl6Gly site had elevated serum TC and LDL-C levels compared with those who carried Arg/ Gly or Gly/Gly (P<0. 05). The apoB100 levels increased in the non-obese females with genotype Arg/Arg and decreased in the obese females with Arg/Gly (P<0. 05 ). The apoA I and apo A Ⅱ levels decreased in the obese and non-obese males with Arg/Arg (P<0. 05). Conclusion The polymorphism in β_2AR gene at Argl6Gly and Gln27Glu is not associated with obesity in Chinese Han population. But they may have certain degree of gender-specific impact on serum TC, LDL-C and apolipoprotein levels.关键词
肥胖/β_2肾上腺素受体/基因多态性Key words
Obese/obesity/β_2 adrenergic receptor /Genetic polymorphism分类
医药卫生引用本文复制引用
吴红梅,白怀,范平,刘瑞,刘宇,刘秉文..中国肥胖患者β_2 肾上腺素受体基因多态性的研究[J].四川大学学报（医学版）,2009,40(6):1056-1061,6.基金项目
国家自然科学基金(批准号39770322)和四川大学华西第二医院科研启动基金资助 （批准号39770322）
