四川大学学报（医学版）2009，Vol.40Issue(6)：1078-1081,4.
五种D-二聚体检测方法用于排除可疑静脉血栓栓塞症的临床评价
Evaluation of Five D-dimer Assays for the Exclusion of Venous Thromboembolism
摘要
Abstract
Objective To evaluate the diagnostic performance of five D-dimer assays for the exclusion of suspected venous thromboembolis (VTE). Methods The plasma D-dimer levels of 75 suspected VTE patients were tested with ELISA, VIDAS DD, DD Plus, Liatest STAGO DD, and NycoCard DD. The results of the five assays were compared with the gold standard of diagnosis of VTE. Results Liatest STAGO DD, DD Plus, VIDAS DD and ELISA had good diagnostic performance for the exclusion of suspected VTE. Liatest STAGO DD had the greatest accuracy for differentiating diagnosis, with 0. 814 of area under the curve (AUC), 96. 7% of sensitivity, and 95. 5% of negative predictive value. ELISA had the greatest specificity (48. 9%). The five assays showed good correlations, with VIDAS DD and Liatest STAGO DD having the greatest correlation coefficient (r=0. 9106). VIDAS DD and Liatest STAGO DD correlated well with ELISA (r=0. 8764 and r=0. 8360 respectively). Conclusion Liatest STAGO DD, DD Plus, and VIDAS DD have good diagnostic performance for the exclusion of VTE. They are easier and quicker to perform and can serve as an alternative test for ELISA. Further validation is needed for clinical applications.关键词
D-二聚体/静脉血栓栓塞症/诊断Key words
D-dimer /Venous thromboembolism/Diagnosis分类
医药卫生引用本文复制引用
周静,孙家瑜,孙加冠,刘琳,徐勇,江虹..五种D-二聚体检测方法用于排除可疑静脉血栓栓塞症的临床评价[J].四川大学学报（医学版）,2009,40(6):1078-1081,4.基金项目
国家自然科学基金(批准号30772153)资助 （批准号30772153）
