来曲唑诱导大鼠多囊卵巢综合征模型卵巢组织中CYP19基因的表达OA北大核心CSCDCSTPCD
Expression of CYP19 gene in ovary tissue of rat model of letrozole-induced polycystic ovary syndrome
目的:研究来曲唑诱导的多囊卵巢综合征(PCOS)模型大鼠卵巢组织中CYP19基因的表达,为该模型的应用提供一定的理论依据.方法:SD大鼠随机分为模型组和对照组,模型组应用来曲唑诱导大鼠PCOS模型.放射免疫法测定大鼠血清性激素水平;H-E染色观察卵巢组织学变化,免疫组织化学、Real time-PCR和免疫印迹法检测CYP19基因在卵巢组织中的表达.结果:模型组血清性激素水平睾酮、黄体生成素、卵泡刺激素浓度显著增高,雌二醇、孕酮浓度降低.模型组C…查看全部>>
Objective:To investigate CYP19 mRNA and protein expression in ovary tissue of rat model of letrozole-induced polycystic ovary syndrome (PCOS), and to provide experimental data for the model application. Methods: Forty rats were divided into two groups randomly, PCOS group administered letrozole once daily during 21 and a control group. Gonadal hormone concentrations in serum were determined by radioimmunoassay, the histologic changes in ovaries were observed…查看全部>>
郭洪胜;李红;全松;邢福祺
广东医学院组织学与胚胎学教研室南方医科大学南方医院妇产科生殖医学中心,广州510515南方医科大学南方医院妇产科生殖医学中心,广州510515南方医科大学南方医院妇产科生殖医学中心,广州510515
医药卫生
多囊卵巢综合征动物模型来曲唑卵巢CYP19
polycystic ovarian syndromeanimal modelletrozoleovaryCYP19
《解剖学杂志》 2009 (5)
611-614,4
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