解剖学杂志2009，Vol.32Issue(5)：623-625,634,4.
人精液一氧化氮含量与男性不育的相关性
Correlation of concentration of nitric oxide in male semen with male infertility
摘要
Abstract
Objective:To explore correlation of concentration of nitric oxide (NO) with sperm apoptosis rate as well as male infertility. Methods:Semen routine examination was done by sperm quality detection system; and NO concentration was tested by nitric oxide reductase. Apoptosis of sperm was examined by terminal deoxynucleotidyl transferase mediated de-oxyuridine triphophate-biotin nick end labeling (TUNEL). The ultrastructure of apoptotic sperm was observed under an e-lectron microscope. Results:The NO concentration in semen was (58. 37±14.14)μmol/l in the male infertility group and (35. 20±8. 23)μmol/l in the control group. The apoptosis rate of sperm was (9. 67±2. 54)% in the control group, while that of the male infertile group was (33. 98±10. 54)%. The NO concentration and the apoptosis rate of sperm in the male infertile group was higher than that in the control group (P<0. 05). Conclusion:Abnormal high level of NO in semen causes the increasing rate of sperm apoptosis, which may be related to male inferticity.关键词
一氧化氮/精子/凋亡/男性不育Key words
nitric oxide/sperm/apoptosis/male infertility分类
医药卫生引用本文复制引用
郑立宏,杨丹,高晓勤..人精液一氧化氮含量与男性不育的相关性[J].解剖学杂志,2009,32(5):623-625,634,4.基金项目
贵阳医学院研究生创新基金(S200701) （S200701）
