解剖学杂志2009，Vol.32Issue(5)：638-640,3.
曲古柳菌素A对肺癌A549细胞凋亡的影响
Effect of trichostatin A on apoptosis of A549 cells
摘要
Abstract
Objective:To investigate the effect of Trichostatin A (TSA) on cell cycle and apoptosis of A549 cells. Methods: The change of cell cycle progression was investigated by flow cytometry. Apoptosis was observed by Annexin-V/PI and protein of Bax was detected by Western blot. Results:Cell cycle was arrested at G_1 /G_0 and G_2/M phase after TSA treatment of 100 nmol/L and 400 nmol/L. TSA induced apoptosis of A549 cells with Annexin-V/PI method. TSA induced the expression of Bax with low concentration, and increased along with increasing of the concentration of TSA. Conclusion:TSA can cause cell cycle arrest in different concentrations, and induce the apoptosis of A549 cell with a low concentration.关键词
肺癌细胞/细胞周期/凋亡/古曲柳菌素A/Bax蛋白Key words
lung cancer cell/cell cycle/apoptosis/trichostatin A/Bax protein分类
医药卫生引用本文复制引用
郝小惠,郭志义,裴鑫,张业,赵偲宇,武慧静,张旋,杨方..曲古柳菌素A对肺癌A549细胞凋亡的影响[J].解剖学杂志,2009,32(5):638-640,3.基金项目
华北煤炭医学院硕博启动基金(BS06002) （BS06002）
