江西农业大学学报2009，Vol.31Issue(5)：812-817,6.
微囊藻毒素-LR对草鱼肝脏超微结构的亚急性毒性影响
Subchronic Effects of Microcystin-LR on the Ultrastructure of Liver of Grass Carp Ctenopharyngodon idella
摘要
Abstract
Microcystin - LR ( MC - LR) is the most frequently studied cyclic heptatoxin produced by cya-nobacteria, which has tremendous negative impact on fish. This study was focused on the ultrastructural alterations in the liver of grass carp Ctenopharyngodon idella injected with MC - LR for a longer time. Grass carp were intraperitoneally injected with MC -LR (purity >98% ) at the dose of 50μ/kg body weight, and the tissues were dissected out after exposure for 1, 2, 7, 14 and 21 days. The pathological changes of the tissues were examined by transmission electron microscopy. The increased intercellular space, cholestasis, infiltration of inflammatory cell, presence of lipid droplets and increasing of lysosome in hepatocytes were observed, however, these symptoms were not observed in hepatocytes 21 days post intraperitoneal injection (dpi). These findings suggest that MC - LR could cause increased intercellular space and other changes except mitochondria and endoplasmic reticulum edema. However, the damaged livers could recover gradually.关键词
草鱼/微囊藻毒素-LR/肝脏/超微结构Key words
grass carp/microcystin - LR/liver/ultrastructure分类
生物科学引用本文复制引用
隗黎丽..微囊藻毒素-LR对草鱼肝脏超微结构的亚急性毒性影响[J].江西农业大学学报,2009,31(5):812-817,6.基金项目
国家自然科学基金项目(20577065)和江西农业大学博士科研启动基金项目(2677) （20577065）
