首页|期刊导航|老年心脏病学杂志（英文版）|Left ventricular hypertrophy in relation to systolic blood pressure and the angiotensin converting enzyme I/D polymorphism in Chinese
老年心脏病学杂志（英文版）2009，Vol.6Issue(3)：131-136,6.
Left ventricular hypertrophy in relation to systolic blood pressure and the angiotensin converting enzyme I/D polymorphism in Chinese
Left ventricular hypertrophy in relation to systolic blood pressure and the angiotensin converting enzyme I/D polymorphism in Chinese
摘要
Abstract
Objective There is little population-based data on the prevalence and the environmental or genetic determinants of left ventricular hypertrophy (LVH) in China. The purpose of this paper is to study LVH in relation to systolic blood pressure and the angiotensin converting enzyme (ACE) insertion/deletion(I/D) polymorphism in Chinese. Methods We recorded 12-lead ECG (CardioSoft, v4.2) in 1365 residents in the Jingning County, Zhejiang Province, China. LVH was defined according to the gender-specific Sokolow-Lyon and Comell product ECG criteria. Results Regardless of whether the Sokolow-Lyon or Comell product ECG criteria was used, the prevalence of LVH (20.7% and 4.8%, respectively) significantly (P<0.0001) increased with male gender (odds ratio [OR] 2.33 and 7.15) and systolic blood pressure (per 10 mm Hg increase, OR 1.46 and 1.33). If the Sokolow-Lyon criteria was used, the prevalence of LVH was also influenced by alcohol intake (OR 1.44, P=0.03) and body mass index (OR 0.83, P=0.0005). The association between the Sokolow-Lyon voltage amplitude and the ACE I/D polymorphism was dependent on antihypertensive therapy (P=0.01). In 1262 untreated subjects, but not 103 patients on antihypertensive medication, the ACE DD compared with Ⅱ subjects had significantly higher Sokolow-Lyon voltage amplitudes (29.8±0.6 vs. 28.0±20.5 mV, P=0.02) and higher risk of LVH (OR 1.74, 95% CI: 1. 12-2.69, P=0.01). Conclusion LVH is prevalent in Chinese, and is associated with systolic blood pressure and the ACE D allele. The genetic association might be modulated by antihypertensive therapy.关键词
left ventricular hypertrophy/ blood pressure/ angiotensin converting enzyme/ genetic polymorphismKey words
left ventricular hypertrophy/ blood pressure/ angiotensin converting enzyme/ genetic polymorphism分类
医药卫生引用本文复制引用
Alexander P. Headley,Yan Li,Yi Zhang,Ji-Yong Ge,Qi-Fang Huang,Ji-Guang Wang..Left ventricular hypertrophy in relation to systolic blood pressure and the angiotensin converting enzyme I/D polymorphism in Chinese[J].老年心脏病学杂志（英文版）,2009,6(3):131-136,6.基金项目
This study was financially supported by grants from the National Natural Science Foundation of China (grants 30871360 and 30871081), Beijing, China, and the Shanghai Commissions of Science and Technology (grant 07JC14047 and the "Rising Star" program 06QA14043) and Education (grant 07ZZ32 and the "Dawn " program 08SG20), and the European Union (InGenious HyperCare LSHM-CT-2006-037093 and HYPERGENES FP7-HEALTH-2007-201550). （grants 30871360 and 30871081）
