南京医科大学学报（自然科学版）2009，Vol.29Issue(11)：1542-1544,3.
川芎嗪对新生鼠缺血缺氧脑损伤HIF-1α表达的影响
The effect of liguistrazine on the HIF-1α expression in neonatal rats with hypoxic ischemic brain damage
李娟 1俞海国 1陆亚东1
作者信息
- 1. 南京医科大学附属南京儿童医院儿科,江苏,南京,210008
- 折叠
摘要
Abstract
Objective: To explore the effect of liguistrazine on the expression of hypoxia-induced factor-1α(HIF-1α)in neonatal rats with hypoxic-ischemic brain damage (HIBD). Methods: Models of 7-day-old neonatal rats with HIBD were established by occluding the left common carotid artery and subjected to inhalation of 8% oxygen. The mice of treated group were injected with liguistrazine intraperitoneally (50 mg/kg) before and after the operation. The expression of HIF-1α in cortex was measured by RT-PCR and im-munohistochemical staining. Results: Although the levels of HIF-1α mRNA and protein expression at 2 h after HIBD were higher than those of sham group,there was no significance (P > 0.05) .While the expression of HIF-1α mRNA and protein were remarkably higher in liguistrazine treated group than those of HIBD group (P < 0.05). Conclusion: Liguistrazine can increase the expression of HIF-α mRNA and protein in neonatal rats with HIBD,which may be the molecular mechanism of its neuroprotective effect.关键词
新生鼠/缺血缺氧脑损伤/川芎嗪/低氧诱导因子Key words
neonatal rat/ hypoxic-ischemic brain damage/ liguistrazine/ HIF-1α分类
医药卫生引用本文复制引用
李娟,俞海国,陆亚东..川芎嗪对新生鼠缺血缺氧脑损伤HIF-1α表达的影响[J].南京医科大学学报（自然科学版）,2009,29(11):1542-1544,3.
