南京医科大学学报（英文版）2009，Vol.23Issue(5)：293-299,7.
Effects of (-)-Epigallocatechin gallate on some protein factors involved in the epidermal growth factor receptor signaling pathway
Effects of (-)-Epigallocatechin gallate on some protein factors involved in the epidermal growth factor receptor signaling pathway
Yinjiu Huang 1Ruiqing Xu 2Baoan Song 3Song Yang 3Li Zhao 1Shouwei Wua1
作者信息
- 1. Bengbu Medical College
- 2. General Hospital of China National Offshore Oil Corp
- 3. Guizhou University
- 折叠
摘要
Abstract
(-)-Epigallocatechin gallate (EGCG), a major polyphenolic constituent of green tea, can inhibit activity of specific receptor tyrosine kinases (RTKs) and related downstream signal transduction pathways, resulting in the control of unwanted cell proliferation. The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important pathways that regulates growth, survival, proliferation and differentiation in mammalian cells. This review addresses the effects of EGCG on some protein factors involved in the EGFR signaling pathway in a direct or indirect manner. Based on our understanding of the interaction between EGCG and these factors, and based on their structures, EGCG could be used as a lead compound for designing and synthesizing novel drugs with significant biological activity.关键词
(-)-Epigallocatechin gallate (EGCG)/ epidermal growth factor receptor (EGFR)/ Signaling pathwayKey words
(-)-Epigallocatechin gallate (EGCG)/ epidermal growth factor receptor (EGFR)/ Signaling pathway分类
医药卫生引用本文复制引用
Yinjiu Huang,Ruiqing Xu,Baoan Song,Song Yang,Li Zhao,Shouwei Wua..Effects of (-)-Epigallocatechin gallate on some protein factors involved in the epidermal growth factor receptor signaling pathway[J].南京医科大学学报（英文版）,2009,23(5):293-299,7.
