天然产物研究与开发2009，Vol.21Issue(5)：740-743,765,5.
水团花黄酮类成分及其体外抗病毒活性
Flavonoids from Adina pilulifera and Their in vitro Antiviral Activity
摘要
Abstract
Six flavonoids were isolated from the ethyl acetate fraction of the ethanol extract of Adina pilulifera. The chemical structures of these flavonoids were determined by spectroscopic analysis,and identified to be naringenin(l) .eriodic-tyol(2) ,quercetin(3) ,naringenin-7-0-β-O-glucopyranside(4) , eriodictyol-7-O-β-D-glucopyranside(5) ,and quercetin-3-O-β-D-glucopyranside(6). Among them,compounds 1,2,4 and 5 were isolated from A. Pilulifera for the first time. Antiviral tests using cytopathic effect(CPE) reduction assay and MTT method revealed that the flavonoid aglycones 1,2 and 3 possess in vitro antiviral activity against both respiratory syncytial virus (RSV) and coxsackie B3 virus ( CVB3) to different extents. In contrast,the flavonoid glucosides 4,5 and 6 did not show any anti-RSV and anti-CVB3 effects.关键词
水团花/黄酮/抗病毒活性Key words
Adina pilulifera/flavonoids/antiviral activity分类
医药卫生引用本文复制引用
李药兰,王辉,范兆永,苏妙贤,薛珺一,李婷,岑颖洲..水团花黄酮类成分及其体外抗病毒活性[J].天然产物研究与开发,2009,21(5):740-743,765,5.基金项目
This work was supported by the National Natural Science Foundation of China(20472024,20772047)and the Natural Science Foundation of Guangdong(04010479,06025165). （20472024,20772047）
