天然产物研究与开发2009，Vol.21Issue(5)：752-756,786,6.
人参皂甙Re对神经内分泌系统功能的影响
Effects of Ginsenoside Re on the Levels of Brain Monoamines Transmitters and Serum Corticosterone in Water Immersion-restraint Rats
徐琲琲 1何文斐 2路金才 3曹颖林1
作者信息
- 1. 沈阳药科大学药学院药理教研室,沈阳,110016
- 2. 温州医学院药学院天然药物化学教研室,温州,325035
- 3. 沈阳药科大学中药学院生药学教研室,沈阳,110016
- 折叠
摘要
Abstract
To investigate the effect of ginsenoside Re on the function of the neuroendocrine system,in water immersion-restraint rats,the contents of brain monoamines transmitters and serum corticosterone were evaluated using high performance liquid chromatography. There was a significant increase of content of brain monoamines transmitters and their metabolites, noradrenaline(NA) , dopamine( DA) , 5-hydroxytryptamine (5-HT) , homovanillic acid( HVA) , 5-hydroxyin-dole-3-acetic acid(5-HIAA) ,and serum corticosterone in pallium,striatum.hypothalamus of water immersion-restraint rats. The elevated level was markedly and dose-dependently reduced by ginsenoside Re(3,6 and 9 mg · kg~(-1)). The data indicated that ginsenoside Re possesses significant effect of recovering the marked increase of neurotransmitters induced by water immersion-restraint stress. This study demonstrates the neuroprotective potential of ginsenoside Re in water immersion-restraint rats.关键词
人参皂甙Re/水浸-束缚应激/单胺类递质/皮质酮Key words
ginsenoside Re/water immersion-restraint stress/monoamines transmitter/corticosterone分类
农业科技引用本文复制引用
徐琲琲,何文斐,路金才,曹颖林..人参皂甙Re对神经内分泌系统功能的影响[J].天然产物研究与开发,2009,21(5):752-756,786,6.
