天然产物研究与开发2009，Vol.21Issue(5)：761-765,5.
蒺藜皂苷对动脉粥样硬化大鼠动脉壁ICAM-1、VCAM-1、PPARα、PPARγ基因表达的影响
Effects of Tribu Saponin from Tribulus terrestris on Gene Expression of ICAM-1, VCAM-1, PPARα and PPARγ in Artery Vessels of Atherosclerotic Rats
摘要
Abstract
To investigate the effects of tribu saponin from Tribulus terrestris(STT) on the gene expression of ICAM-1, VCAM-1 ,PPARα and PPAR-γ in artery vessels of atherosclerotic rats,the model rats of atherosclerosis were established by feeding with high cholesterol diet and injecting with vitamin D_3. The rats were divided into normal group, model group,simvastatin group and 3 groups with SIT. Semi-quantitative RT-PCR was used to detect ICAM-1, VCAM-1, PPARα and PPARγ gene expression in artery vessels. The changes of gene expression of ICAM-1, VCAM-1 , PPARα and PPARγ in artery vessels in each group were analyzed. The results showed that ICAM-1 and VCAM-1 gene expression levels in the model group were significantly higher than those of normal group (P <0.01) , while the PPARα, PPARγ gene expression in the model group were significantly lower than those of normal group ( P < 0.01); Compared with model group,the ICAM-1 and VCAM-1 gene expression levels in each medicated group were significantly lower (P<0.01-P<0.05) and the PPARα and PPAHγ gene expression levels in each medicated group were significantly higher(P < 0.01). STT can down regulate the gene expression of ICAM-1, VCAM-1 and up regulate the gene expression of PPARα, PPARγ in artery vessels of arterosclerotic rats,which may account for the anti-arteriosclerosis effects of STT.关键词
蒺藜皂苷/动脉粥样硬化/细胞间黏附分子-1/血管细胞黏附分子-1/过氧化物酶增殖体激活受体Key words
tribu saponin Tribulus terrestris/ atherosclerosis/ intercellular adhesion molecule-1/ vascular cell adhesion-molecule-1/ peroxisome proliferators-activated receptors分类
医药卫生引用本文复制引用
石昌杰,瞿伟菁,高娟..蒺藜皂苷对动脉粥样硬化大鼠动脉壁ICAM-1、VCAM-1、PPARα、PPARγ基因表达的影响[J].天然产物研究与开发,2009,21(5):761-765,5.基金项目
国家自然科学基金(30370158) （30370158）
