摘要
Abstract
OBJECTIVE:To explore the inducing factors of immunological rejection following corneal transplantation,in addition,to compare the therapeutic effects among various immunosuppressive drugs.METHODS:Chinese Journal Full-text Database was retrieved with search terms of corneal transplantation,immunologic rejection,experiment,cytokine,and drugs from January 1999 to June 2009.The language was restricted in Chinese using survival time of corneal grafts as evaluation index.Animal experiments and clinical research regarding immunological rejection following corneal transplantation were included,and articles concerning other treatment methods for ceratonosus were excluded.RESULTS:A total of 570 papers were obtained by initial search with computer.According to inclusion criteria,papers regarding animal experiments and clinical research regarding immunological rejection following corneal transplantation were analyzed.At present,glucocorticoid and ciclosporin were mainly used in preventing and treating immunological rejection following corneal transplantation,however,the long term using of these drugs would result in severe complications.Interleukin-1 receptor antagonist can replace ciclosporin A as immunosuppressive drug,which can reduce side effect and extent the survival time of corneal grafts.Rapamycin is a new immunosuppressive agent with good effects and low toxicity,which exhibits significant effects on anti rejection.Tacrolimus drug delivery system can maintain the high drug concentration in aqueous humor for a long time,inhibit expressions of interleukin 2 receptor α,monocyte chemoattractant protein 1,Fas and FasL mRNA,which can suppress immunological rejection following high-risk corneal transplantation.CONCLUSION:Realizing inducing factors,contributory factors and mechanisms of immunological rejection following corneal transplantation take an important part in preventing immunological rejection and increasing successful rate of corneal grafts.关键词
角膜移植/免疫排斥/实验/细胞因子/药物分类
基础医学
