中国组织工程研究与临床康复2009，Vol.13Issue(42)：8229-8232,4.DOI:10.3969/j.issn.1673-8225.2009.42.005
多孔碳酸化羟基磷灰石水泥修复双侧股骨髁骨缺损:同体随机对照16周组织学结果验证
Repairing bilateral femur condular defects using porous carbonated hydroxyapatite cement: A 16 weeks result verification of homobody control experiment
摘要
Abstract
BACKGROUND: Newly porous carbonated hydroxyapatite cement (PCHC) was prepared using foaming agent-hole technique,which possess merits of CHC with porous structures.OBJECTIVE: To verify the effective of PCHC for repairing bone defects. DESIGN, TIME AND SETTING: The homobody contrast observation was performed at the Department of Orthopedics, and animal experiment center, General Hospital of Chinese PLA between January 2000 and August 2002. MATERIALS: The calcium carbonate and calcium phosphate was combined and solidified to prepare CHC with high temperature calcinations, and then foaming agent was added to produce carbon dioxide gas to form porosity. METHODS: The animal model of bone defect was made on the bilateral femur of 10 New Zealand white rabbits, which were randomly divided into the experimental group (the defect was repaired with PCHC) and the control group (repaired with CHC). MAIN OUTCOME MEASURES: All the animals were sacrificed under anesthesia at weeks 2, 4, 8, 12 and 16 after operation. The repair status of specimen was studied by X-ray and histological observation. RESULTS: The bone defect was completely filled by PCHC, and the interface between bone and PCHC was tightly combined with good biocompatibility. There was new bone formation in the control group, increased with time prolonged, but no new bone was found in the center of materials. The 16-week imaging showed that the PCHC would gradually degrade as the implant time prolonged and it would be substituted by new born bone. At the same time, the visual area of material in the control group was obviously reduced. CONCLUSION: PCHC has good biological compatibility, processes the character of immobilization, which can be used as bone substitute to repair the bone defects.关键词
多孔碳酸化羟基磷灰石水泥/骨缺损/组织学分类
医药卫生引用本文复制引用
姚琦,黄鹏,唐佩福,王继芳..多孔碳酸化羟基磷灰石水泥修复双侧股骨髁骨缺损:同体随机对照16周组织学结果验证[J].中国组织工程研究与临床康复,2009,13(42):8229-8232,4.基金项目
国家自然科学基金项目(39670731)资助 （39670731）
