中国组织工程研究与临床康复2009，Vol.13Issue(44)：8764-8766,3.DOI:10.3969/j.issn.1673-8225.2009.44.038
异体表皮干细胞与猪脱细胞真皮构建复合皮移植6例
Composite skin transplantation with allogeneic epidermal stem cells and porcine acellular dermal in six cases
廖立新 1曾元临 1陈刚泉 1李莉1
作者信息
- 1. 南昌大学第一附属医院烧伤科,江西省南昌市,330006
- 折叠
摘要
Abstract
Six patients with deep bum were from Department of Burn,the First Affiliated Hospital of Nanchang University between January 2005 and October 2006.They were all Ⅲ degree burn of limbs.Composite skin made with xenogenic(porcine)acellular dermal and allogeneic epidermal stem cells was provided by Burn Center in the First Affiliated Hospital of Nanchang University.After debridement and sterilization,composite skin transplantation and autologous split-thickness skin transplantation were performed.A total of 96 autologous split-thickness skins and 12 composite skins were transplanted.In composite skin transplantation,the composite skin was cut into 1.5 cm×1.5 cm and transplanted on the wound with rough surface opposite to wound.In autologous split-thickness skin transplantation,autologous split-thickness skin placed on vaseline gauze and cut into 1.5 cm×1.5 cm,and then transplanted around of the composite skin.At 3 days after transplantation,the composite skin and autologous split-thickness skin adhered well with wounds,which showed pink and wet.At 7 days,the majority of the composite skin and autologous split-thickness skin were survival.At 14 days,the majority of skins were close to fusion.At 21 days,the wound had basically healed.There was no significant difference in the number of skin graft survival between the composite skin and autologous split-thickness skin(P＞0.05).But the healing area of the composite skin was significantly smaller than that of autologous split-thickness skin because the composite skin had the poor extension(P＜0.01).There was no patient had bad reaction.The results suggested that the artificial skin made with epidermal stem cells and porcine acellular dermal transplanted to the affected areas could establish blood circulation and maintain a certain degree of vitality,which could achieve the purpose of covering the wound,preventing infection and preventing the loss of body fluids.关键词
异种/脱细胞真皮/表皮干细胞/烧伤/移植分类
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廖立新,曾元临,陈刚泉,李莉..异体表皮干细胞与猪脱细胞真皮构建复合皮移植6例[J].中国组织工程研究与临床康复,2009,13(44):8764-8766,3.
