中国组织工程研究与临床康复2009，Vol.13Issue(42)：8325-8328,4.DOI:10.3969/j.issn.1673-8225.2009 42.028
锶在骨组织工程中的研究与应用
Application and study of strontium for bone tissue engineering
王会学 1叶晓健1
作者信息
- 1. 解放军第二军医大学长征医院科,上海市,200003
- 折叠
摘要
Abstract
OBJECTIVE: To summarize current situation of the strontium element in bone tissue engineering and to analyze its questions and potential perspective. DATA SOURCE: "strontium, bone" were indexed as key words in Databases including ScienceDirect and CNKI from January in 1990 to March in 2009. DATA SELECTION: Reviews and experimental articles relevant to strontium and bone were accepted, excluding those articles which were repetitive in content and related to radioactive strontium. MAIN OUTCOME MEASURES: ①osteoclast activity; ②osteoblastic proliferation;③bone inducibility. RESULTS: Total 216 articles were gotten by computers according to criteria, of which 41 articles were summarized and analyzed. The outcomes ran as follow: strontium, is one of trace elements in human body, the overwhelming majority of which exists in bone tissue. Its functions are to adjust bone frame and structure, improve bone strength and develop physiological activity of osteocytes. It has been proved by experiments that strontium in bone tissue is able to resist bone resorption and increase osteoplastic function, to inhibit osteoclast activity and develop osteoblastic activity, as well as to promote the deposition of bone minerals. The mechanical strength, solubleness and the capability to induce ossification of the materials could be improved obviously when strontium was added, which were formed of hydroxyapatite and tricalcium phosphate. Another testimony which can prove the function of strontium was that oral salts rich in strontium can treat osteoporosis. CONCLUSION: The requisite importance to strontium in study of bone tissue engineering should be paid because the physiological action to develop growth and differentiation of osteocytes and accelerate deposition of bone matrix.关键词
锶/骨组织工程/羟基磷灰石/磷酸三钙/雷诺酸锶分类
医药卫生引用本文复制引用
王会学,叶晓健..锶在骨组织工程中的研究与应用[J].中国组织工程研究与临床康复,2009,13(42):8325-8328,4.
