摘要
Abstract
OBJECTIVE: To explore the characteristics of drug release of chitosan as insulin vector, and to prospect application of polymer materials to insulin vector. METHODS: We researched China Journal Full-text Database in Chinese from January 1999 to June 2009, and Pubmed database in English from January 1999 to June 2009 with the key words of "insulin, carriers, chitosan, liposomes, polymer". Drug bioavailability, embedding rate, release rate were used as evaluation indexes. Studies concerning chitosan and other biological materials as insulin carrier for oral use were included. Studies describing injection administration and other administration methods were excluded. RESULTS: 543 literatures were selected by computer. According to exclusion criteria, characteristics of drug release of chitosan and other biomaterials as insulin carriers were analyzed. Chitosan and its derived nanoparticle as insulin administration system have received high attention, and presented special nanometer effects in mucosa administration system, not only can change drug dynamics, but also prolong residence time in mucosa, change membrane transport mechanism, enhance drug permeability to membrane. These effectively overcome biological barrier such as enzyme, solve some problems such as easy to inactivation and short half-life period of insulin in vivo. Recently, drug release research of insulin carrier has obtained some progresses, but we still face many difficulties, including low entrapment efficiency, limited absorption, immature evaluation method for preparation quality, difficult to control, high cost, destroy to absorption area, and effects on human organs. With the appearance of many new functional polymers and rapid development of medical preparation industry, polymer carrier has been widely used in the research and development of new drugs. CONCLUSION: Biocompatibility and biodegradability should be firstly considered when selecting insulin drug carrier system. Synthesis of insulin carrier, connection manner of insulin and carrier, effects of spacer on drug release function, relation between carrier structure and monoclonal antibody specific have crucial effects on drug release of insulin carrier.关键词
胰岛素/载体/壳聚糖/脂质体/聚合物分类
基础医学
