中国组织工程研究与临床康复2009，Vol.13Issue(34)：6793-6796,4.DOI:10.3969/j.issn.1673-8225.2009.34.045
生物新材料细菌纤维素与深Ⅱ度烧伤大鼠皮肤的创面愈合
Effect of bacterial cellulose on the wound healing of deep second-degree burn in rats
摘要
Abstract
BACKGROUND: Bacterial cellulose, a new nanometer biomaterial, benefits the growth of skin tissue and limits the infection. It may provide advantageous conditions for the biomaterials dressing and temporary skin in the burnt patients and chronic ulcer patients. OBJECTIVE: To study the possibility of bacterial cellulose in the treatment of deep second-degree burn in rats. DESIGN, TIME AND SETTING: An observational experiment was perforemd at the Central Laboratory of Sixth People's Hospital of Shanghai Jiao Tong University from June to November 2008. MATERIALS: M12 was used to produce non-soluble gel membrane when it was cultured for 6 days at a constant temperature of 30℃, and then the sample was boiled for 20 minutes in 0.1 mol/L NaOH solution. Ivory semitransparent bacterial cellulose was obtained following the removals of thallus in liquid membrane and residual culture medium. METHODS: Skin burn in a size of 2.0 cm×2.0 cm was made in bilateral sides of spinal cord on back with self-made wound meter. One side was treated with bacterial cellulose dressing and sutured, taking as experimental side. While the other side served as control side without dressing. MAIN OUTCOME MEASURES: At days 4, 7, 14, 21 and 28 after operation, the healing rate of skin burn in rats was calculated, and the skin wound and healing were observed under light microscope. RESULTS: All animals were alive normally without the presence of wound infection. Compared with control side, the wound healing rate of treated side significantly improved at day 21 after operation; there was no significant difference between the treated side and control side at other time points (P < 0.01). The histological results indicated that the pathological lesion and healing had no significant differences between the two sides. CONCLUSION: Bacterial cellulose can promote the healing of skin burn wound to a certain degree.关键词
细菌纤维素/烧伤/生物材料分类
基础医学引用本文复制引用
马霞,张华,陈世文..生物新材料细菌纤维素与深Ⅱ度烧伤大鼠皮肤的创面愈合[J].中国组织工程研究与临床康复,2009,13(34):6793-6796,4.基金项目
the Natural Science Foundation of Shandong Province, No. Q2006FO8 （）
China Postdoctoral Scientific Program, No. 20080430659 （）
Shanghai Institute of Technology Program, No. YJ2008-14.山东省自然科学基金项目资助(Q2006F08) （Q2006F08）
中国博士后科学基金项目资助(20080430659) （20080430659）
上海应用技术学院人才引进项目(YJ2008-14) （YJ2008-14）
