中国组织工程研究与临床康复2009，Vol.13Issue(36)：7171-7174,4.DOI:10.3969/j.issn.1673-8225.2009.36.035
脂肪源性间充质干细胞联合造血干细胞共移植治疗顽固性重型再生障碍性贫血2例
Cotransplantation of haploidentical mesenchymal stem cells and hematopoietic stem cells in the treatment of two child patients with refractory severe aplastic anemia
摘要
Abstract
To assess the efficacy of cotransplantation of haploidentical mesenchymal stem calls (MSC) and hematopoietic stem cells (HSC) in the treatment of refractory severe aplastic anemia, Two child patients with refractory severe aplastic anemia admitted to Henan Institute of Haematology from August 2002 to December 2007 were selected. Adipose tissue-derived MSCs (AMSCs) were separately originated from haploidentical mother and peripheral blood stem calls (PBSCs) from HLA-identical sibling brother or sister of patients. The patient 1 received a cotransplantation of PBSCs and AMSCs (1 × 106/kg) at a dose of 4.5 × 108 mononuclear calls/kg (containing 4.41 × 106 CD34+ calls/kg and 0.11 ×105 CD3+ cells/kg); the patient 2 received a second PBSCT at a dose of 6.5 × 108mononuclear cells/kg (containing 4.62×106 CD34+ cells/kg and 0.12×105 CD3+ cells/kg) and AMSC (1 × 108/kg) from his haploidentical mother. The results show that the cotransplantation was successful. During the two years of follow up, the two patients exhibited good condition, with no other treatment or transfusion dependence.关键词
重型再生障碍性贫血/植入失败/间充质干细胞/共移植分类
医药卫生引用本文复制引用
张龚莉,李宁,宋永平,林全德,魏旭东,房佰俊..脂肪源性间充质干细胞联合造血干细胞共移植治疗顽固性重型再生障碍性贫血2例[J].中国组织工程研究与临床康复,2009,13(36):7171-7174,4.基金项目
河南省杰出青年基金(0612000900) （0612000900）
Supported by:Henan Outstanding Youth Foundation,No.0612000900 （）
