畜牧兽医学报2009，Vol.40Issue(11)：1669-1674,6.
交感神经对妊娠早期小鼠子宫内膜发育的影响
Effect of Sympathetic Nerve on Development of Endometrium in Mice During Early Pregnancy
摘要
Abstract
The objective of the present study was to explore the effect of sympathetic nerve system on development of endometrium in mice during early pregnancy(Embryo day 1-9). The adult fe-male kun-ming mice were treated by intraperitoneal injection of 6-OHDA (100 mg·kg~(-1) body weight), which will damage the sympathetic nerve. After 6-OHDA treatment, the levels of ser-um 17β-estradiol, the development of uterine gland and the proliferation of endometrium cells during early pregnancy were investigated by means of RIA, histology and immunohistochemistry. The results were demonstrated as follows: (1) the levels of 17β-estradiol in 6-OHDA treated group were decreased by 63.4%, 35.7% and 25.5% in Embryo day 1 (E1) (P<0.01), E5 (P< 0.05) and E7 (P<0.05), respectively, but were significantly increased by 79.30% and 156.7% in E3 (P<0.05) and E9 (P<0.01); (2) the proportion of uterine endometrial glands in 6-OH-DA treated group was declined by 37.5%, 38.6%, 41.8%, 61.4% and 58.1% in E1, E3, E5, E7 and E9, respectively (P<0.01); (3) the proliferative rate of endometrial cell during early pregnancy was decreased by 27.2%, 30.2%, 40.7%, 27.2% and 27.7% in E1, E3, E5, E7 and E9, respectively (P<0.01). In conclusion, the sympathetic nerves can regulate the secretion of estrogen and reconstruction of endometrium, further then regulate the animals implantation and development in early pregnancy.关键词
交感神经/妊娠早期/17β-雌二醇/子宫腺/增殖细胞核抗原Key words
sympathetic nerve/ early pregnancy/ 17β-estradiol/ uterine gland/ proliferating cell nuclear antigen分类
医药卫生引用本文复制引用
赵娇慧,陈耀星,王子旭,董玉兰,白永平,谢电..交感神经对妊娠早期小鼠子宫内膜发育的影响[J].畜牧兽医学报,2009,40(11):1669-1674,6.基金项目
国家自然科学基金(30671514) （30671514）
