针刺研究2009，Vol.34Issue(1)：13-15,42,4.
电针"水沟"对脑缺血大鼠海马降钙素基因相关肽、神经肽Y含量的影响
Influence of Electroacupuncture of "Shuigou"(GV 26)on Hippocampal CGRP and NPY Contents in Cerebral Ischemia Rats
摘要
Abstract
Objective To observe the effect of electroacupuncture (EA) on the contents of hippocampal calcitonin gene-related peptide (CGRP) and neuropeptide Y (NPY) in cerebral ischemia (CD rats. Methods Forty SD rats were randomly divided into normal control, sham operation (sham), model and EA groups with 10 cases in each. Cl model was duplicated by middle cerebral artery occlusion. EA (2 Hz, 1 mA, continuous waves) was applied to "Shuigou" (GV 26) for 30 min, once daily for 5 days. Hippocampal tissue was taken for assaying the contents of CGRP and NPY with radioimmunoassay. Results Compared with sham group and normal control group, hippocampal CGRP content in model group decreased apparently (P<0. 01), while NPY content of model group increased significantly (P<0. 01). Compared with model group, hippocampal CGRP in EA group increased considerably (P<0. 01) and NPY content decreased obviously (P<0. 01). Conclusion Electroacupuncture of GV26 can effectively adjust hippocampal CGRP and NPY contents in Cl rats, which may contribute to its effect in improving cerebral ischemia.关键词
脑缺血/电针/海马/降钙素基因相关肽/神经肽YKey words
Cerebral ischemia/ Electroacupuncture/ Hippocampus/ CGRP/ NPY分类
医药卫生引用本文复制引用
黄伟,吴绪平,丁昀,王亚文,王述菊,孙国杰..电针"水沟"对脑缺血大鼠海马降钙素基因相关肽、神经肽Y含量的影响[J].针刺研究,2009,34(1):13-15,42,4.基金项目
国家中医药管理局中医药科学技术研究专项基金(04-05 JP 40) （04-05 JP 40）
