中国病理生理杂志2009，Vol.25Issue(11)：2204-2207,4.
糖皮质激素吸入对哮喘患儿外周血CD4~+CD25~+调节性T细胞水平的影响
Effects of glucocorticoid inhalation on the levels of CD4~+CD25~+ regulatory T cells in peripheral blood of asthmatic children
摘要
Abstract
AIM: To investigate the effect of glucocorticoid inhalation on the levels of CD4~+CD25~+ regulatory T cells in peripheral blood of asthmatic children. METHODS: Glucocorticoid inhalator was inhaled by 70 children with attack asthma. The levels of CD4~+CD25~+ Tr in peripheral blood of asthmatic children were tested by flow cytometry (FCM). RESULTS: The CD4~+CD25~+ Tr levels in peripheral blood of asthmatic children were (5.62% ± 1.29% ) and (7.05% ± 1.61%) before and after of regulated glucocorticoid inhalation, respectively (P<0.01). The Tr levels were (7.56% ± 1.88% ) , (7.09% ± 1.23% ) and (6.11% ± 1.96% ) in the complete control group, part control group and poor control group, respectively ( P < 0.05 ). The Tr level in formal treatment group (7.05% ±1.61%) was higher than that in irregular treatment group ( 5.91 % ± 1.76% ), P < 0.01.CONCLUSION: The level of CD4~+CD25~+ Tr is remarkable increased by regulated glucocorticoid inhalation, and the level of Tr can reflect the effects of glucocorticoid inhalation.关键词
CD4~+CD25~+调节性T细胞/哮喘/糖皮质激素类/吸入疗法/儿童Key words
CD4~+CD25~+ regulatory T cells/ Asthma/ Glucocorticoids/ Inhalation therapy/ Child分类
医药卫生引用本文复制引用
黄花荣,刘甜甜,魏菁,檀卫平,吴葆菁,麦贤弟..糖皮质激素吸入对哮喘患儿外周血CD4~+CD25~+调节性T细胞水平的影响[J].中国病理生理杂志,2009,25(11):2204-2207,4.基金项目
广东省自然科学基金资助项目(No.06021299) （No.06021299）
