中国当代儿科杂志2009，Vol.11Issue(11)：881-884,4.
儿童急性淋巴细胞白血病nm23-H_1基因表达及其与免疫分型的关系
Expression of nm3-H_1 gene in childhood acute lymphoblastic leukemia and the rela-tionship between nm23-H_1 expression and immunophenotype
摘要
Abstract
Objective To study the expression of nm23-H_1 gene in children with acute lymphoblastic leukemia (ALL) and the relationship between nm23-H, expression and immunophenotype. Methods nm23-H_1 expression was measured by semiquantitative RT-PCR in children with ALL (newly diagnosed, n =40; remission, n = 32; relapse, n = 16; refractory, n =3). Twenty normal children served as the control group. The relationship between nm23-H_1 expression and immunophenotype was evaluated. Results The expression of nm23-H_1 in the newly diagnosed ALL group was significantly higher than that in the control (P<0. 01 ) and the remission groups (P<0.01 ). There was no difference in the nm23-H, expression between the remission and the control groups. The expression of nm23-H_1 in the relapse group was significantly higher than that in the control (P < 0. 01) and the remission groups (P < 0.01), and similar to that in the newly diagnosed ALL group. The three children with refractory ALL had higher nm23-H, expression. Both the positive rate and expression of nm23-H, in children with T-lineage ALL were higher than in children with B-lineage ALL (P < 0.05 ). Conclusions The expression level of nm23-H_1 varies with the stages of ALL. Newly diagnosed, relapsed and refractory ALL children have higher nm23-H_1 expression. High nm23-H_1 expression may be associated with a poor prognosis and relapse. A higher expression of nm23-H_1 in children with T-ALL may be contributed to a low remission rate and a poor prognosis.关键词
nm23-H_1/淋巴细胞白血病/免疫分型/儿童Key words
nm23-H_1/ Lymphoblastic leukemia/ Immunophenotype/ Child分类
医药卫生引用本文复制引用
宁芳,才绍江,张同娟,刘旭昕,张玉梅..儿童急性淋巴细胞白血病nm23-H_1基因表达及其与免疫分型的关系[J].中国当代儿科杂志,2009,11(11):881-884,4.基金项目
哈尔滨市科学技术局科技创新人才研究专项资金项目(2006RFQQS058). （2006RFQQS058）
