高浓度氧对新生大鼠肺血管内皮生长因子及其受体表达的影响OA北大核心CSCDCSTPCD
Effects of prolonged exposure of high concentration of oxygen on expression of vascu-lar endothelial growth factor and its receptors in neonatal rat lungs
目的 研究持续吸入75%氧对新生大鼠肺血管内皮生长因子(vascular endothelial growth factor,VEGF)及其受体(VEGFR1和VEGFR2)表达的影响,探讨较高浓度吸氧对肺血管发育的影响及与支气管肺发育不良(bronchopulmonary dysplasia,BPD)的关系.方法 新生足月Spragne-Dawley大鼠48只,随机分为对照组和实验组.实验组生后12 h开始持续吸入75%氧气.分别于实验开始后的…查看全部>>
Objective To study the effects of prolonged 75% oxygen exposure on the expression of vascular endothelial growth factor ( VEGF) and its receptors ( VEGFR1 and VEGFR2) in the neonatal rat lungs and to elucidate the effects of prolonged exposure of high concentration of oxygen on lung vascular development and its relationship with bronchopulmonary dysplasia ( BPD). Methods Forty-eight Sprague-Dawley rat pups were randomly exposed to air (control group) and 75%…查看全部>>
冯海燕;陆爱珍;张晓渡;王立波;陈超
复旦大学附属儿科医院,上海,201102复旦大学附属儿科医院,上海,201102复旦大学附属儿科医院,上海,201102复旦大学附属儿科医院,上海,201102复旦大学附属儿科医院,上海,201102
医药卫生
血管内皮生长因子受体血管内皮生长因子高浓度氧新生大鼠
Vascular endothelial growth factor Receptors, vascular endothelial growth factor High concentration of oxygen Neonatal rats
《中国当代儿科杂志》 2009 (11)
927-930,4
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