中国临床药理学与治疗学2009，Vol.14Issue(1)：90-93,4.
罗哌卡因蛛网膜下隙阻滞分娩镇痛的剂量-效应关系
Dose-effect relationship of intrathecal ropivacaine for labor analgesia
摘要
Abstract
AIM: To determine the dose-effect relationship of intrathecal ropivacaine for labor analgesia.METHODS: One hundred premolars in active labor were included in this randomized trial.Ropivacaine was intrathecally administered in a dose of 1.0, 1.5, 2.2 or 3.3 mg.Premolars were considered responders to spinal analgesia if the visual analog scale score for pain was less than 3 cm within 10 min.Group-specific dose-response curves were constructed using a probit regression model.RESULTS: The ED_(50) and ED_(95) of ropivacaine were 1.50 mg (95 % confidence interval: 1.31 - 1.70 mg) and 2.93 mg(95% confidence interval: 2.42 -4.16 mg), respectively.The relationship between the probit of effective analgesic ratio of premolars and the log of dosage of intrathecal ropivacaine was established.Regression equation was Probit(Z) = -1.00478 + 5.67816(log of dosage).CONCLUSION: The ED_(50)) and ED_(95) of ropivacaine are 1.50 mg and 2.93 mg, respectively.关键词
罗哌卡因/蛛网膜下隙/分娩镇痛/剂量/效应Key words
ropivacaine/subarachnoid space/labor analgesia/dosage/effect分类
医药卫生引用本文复制引用
蔡晓雷,钟惠珍,甘果,袁力勇,黄建平,方春峰..罗哌卡因蛛网膜下隙阻滞分娩镇痛的剂量-效应关系[J].中国临床药理学与治疗学,2009,14(1):90-93,4.基金项目
宁波市医学科技项目(2006009) （2006009）
宁波市优秀中青年卫生技术人才项目(2007201) （2007201）
