中国临床药理学与治疗学2009，Vol.14Issue(4)：448-454,7.
转运体在药物排泄中的作用及在新药研发中的意义
Role of transporters in the drug excretion and its significance in new drug development
摘要
Abstract
This review is mainly concerned about the effects of drug transporters on drug excretion and the possibility in the development and clinical application of new drugs. The understanding of the properties of transporters enables us to develop novel drugs, which can increase the site-directional drug delivery, or avoid the distribution to other organs, thereby increase the therapeutic effects and reduce the chance of toxic effects. Furthermore, the research of drug transporter-mediated drug-drug interactions and enterohepat-ic cycle, is able to guide us a more reasonable, safe and effective clinical medication. It is well accepted in recent years that the pharmacokinetic properties of a new drug should be studied in its early stage of development. Additionally, high-through screening system established on transporters is bound to be an effective tool to accelerate the development of new drugs.关键词
药物转运体/肝胆排泄/肾排泄/药物靶向性Key words
drug transporter/ hepatic biliary excretion / renal excretion/ drug targeting分类
医药卫生引用本文复制引用
王磊,李宁,陈西敬..转运体在药物排泄中的作用及在新药研发中的意义[J].中国临床药理学与治疗学,2009,14(4):448-454,7.基金项目
国家高技术研究发展计划("863"计划)(2007AA02Z171) （"863"计划）
国家自然科学基金(30472060)的资助 （30472060）
