中国临床药理学与治疗学2009，Vol.14Issue(2)：199-202,4.
氧驱动雾化吸入布地奈德混悬液和复方异丙托溴铵溶液对慢性阻塞性肺疾病急性加重期Ⅱ型呼吸衰竭患者的影响
Effects of inhalation of budesonide suspension and compound ipratropium bromide solution with oxygen driven nebulizers on patients with acute exacerbation of chronic obstructive pulmonary disease and type Ⅱ respiratory failure
何剑波 1颜孙舜 1徐慧 1戴元荣 1吴成云 1翁海霞 1吴立琴1
作者信息
- 1. 温州医学院附属第二医院呼吸内科,温州,325027,浙江
- 折叠
摘要
Abstract
AIM: To study the effect of inhalation of budesonide suspension and compound ipratropium bromide solution with oxygen driven nebulizers on arterial blood gas analysis and lung function of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and respiratory failure type Ⅱ and to observe the side effects. METHODS: Thirty AECOPD hospitalization patients were selected in the study, each one inhaled 2 mL budesonide suspension and 2.5 mL compound ipratropium bromide solution with oxygen driven nebulizers (oxygen flow 5 L/min) for about 20 minutes. Arterial blood gas and peak expiratory flow (PEF) were measured before inhalation of budesonide suspension and compound ipratropium bromide solution and half an hour after inhalation finished , at the same time, the percutaneous oxygen saturation, consciousness, breathing, heart rate were monitored. RESULTS: The inhalation of budesonide suspension and compound ipratropium bromide solution led to the increase in PaO_2 and PEF, a decrease in PaCO_2 . There were significantly positive correlations between the improvement rate of PEF and the decrease of PaCO_2 .The side effects were tolerable. CONCLUSION: Inhalation of budesonide suspension and compound ipratropium bromide solution with oxygen driven nebulizers could treat the patients with AECOPD and respiratory failure type Ⅱ with hypoxia and hypercapnia by improving their lung function. The usage of oxygen driven nebulizers has good efficacy and safety for the patients with AECOPD and respiratory failure type Ⅱ.关键词
慢性阻塞性肺疾病/Ⅱ型呼吸衰竭/氧驱动雾化/布地奈德混悬液/复方异丙托溴铵溶液Key words
chronic obstructive pulmonary disease / respiratory failure type Ⅱ/ oxygen driven nebulizers/ budesonide suspension/ compound ipratropium bromide solution分类
医药卫生引用本文复制引用
何剑波,颜孙舜,徐慧,戴元荣,吴成云,翁海霞,吴立琴..氧驱动雾化吸入布地奈德混悬液和复方异丙托溴铵溶液对慢性阻塞性肺疾病急性加重期Ⅱ型呼吸衰竭患者的影响[J].中国临床药理学与治疗学,2009,14(2):199-202,4.
