中国临床药理学与治疗学2009，Vol.14Issue(5)：541-545,5.
进展期胃癌术前顺铂腹腔内、静脉化疗药代动力学的比较研究
Study on cisplatin pharmacokinetics:preoperative intraperitoneal administration versus intravenous chemotherapy with cisplatin for advanced gastric carcinoma
李豪侠 1陈晓亮 1马志敏2
作者信息
- 1. 杭州师范大学附属医院中西医结合科,杭州,310015,浙江
- 2. 浙江大学医学院附属第一医院肿瘤外科,杭州,310003,浙江
- 折叠
摘要
Abstract
AIM: To compare the characteristics of cisplatin pharmacokinetics: preoperative intraperitoneal administration versus intravenous chemotherapy with cisplatin for advanced gastric carcinoma. METHODS: 50 patients with resectable advanced gastric cancer were randomly divided into 2 groups: 26 cases with preoperative intraperitoneal administration of cisplatin (I.p. Group) and 24 cases with preoperative intravenous administration of cisplatin (I. V. Group) . Each patient was given 60 mg/m cisplatin intraperitoneally or intravenously. The peritoneal fluid, blood from gastric sinistral vein and peripheral blood were taken on the 180th minutes after the drug was administrated. Cancer tissues and normal tissues beside the cancer tissue were collected at the 270th minutes during operation. Another 8 cases were used to study the pharmacokinetics of intraperitoneal administration and intravenous chemotherapy with cisplatin. The concentrations of cisplatin in different samples were measured by the flameless type of atomic absorption spectrometry. RESULTS:
The high cisplatin concentration in abdominal cavity could maintain for fairly longer time by intraperitoneal administration more than by intravenous administration. And the plasma concentrations of cisplatin in peritoneal cavity were similar by the two injection styles. The AUC with intraperitoneal administration was about five times than that with intravenous administration. The cisplatin concentrations of peritoneal fluid and vena gastrica sinistra blood in the I.p. Group were 23.4 and 2.53 times higher than those in the I. V. Group respectively (P < 0.01) . The cisplatin of the cancer tissue in the I.p. Group was higher than that in the I. V. Group( P < 0.05). CONCLUSION: The intraperitio-neal cisplatin chemotherapy has better pharmacokinetics parameters and could be a useful accessory treatment for the advanced gastric carcinoma cancer.关键词
进展期胃癌/顺铂/药代动力学Key words
advanced gastric carcinoma/ cisplatin/ pharmacokinetics分类
医药卫生引用本文复制引用
李豪侠,陈晓亮,马志敏..进展期胃癌术前顺铂腹腔内、静脉化疗药代动力学的比较研究[J].中国临床药理学与治疗学,2009,14(5):541-545,5.
