中国临床药理学与治疗学2009，Vol.14Issue(3)：241-244,4.
靶向诱导DNA甲基化与肿瘤治疗研究进展
Advances in targeted induction of DNA methylation and cancer therapy
马爱妞 1王永祥 1周向军1
作者信息
- 1. 上海交通大学药学院分子与系统药理学实验室,上海,200240
- 折叠
摘要
Abstract
DNA methyktion is one of the important events in epigenetic regulation. It inhibits gene expression in the transcription level resulting in gene silencing. Recent studies revealed that DNA methylation not only occurs naturally in organism, but also targeting induced by special RNA/DNA. Oncogenesis exist abnormally low methylation in tumor cells, which is considered to be one of the pathogeneses of tumors. Thus inhibition of the expression of oncogenesis and the growth of tumor by targeted induction of DNA methylation provides a new way for cancer therapy. This review summarizes the effects of targeted induction of DNA methylation on cancer therapy in preclinical studies.关键词
DNA甲基化/ 基因沉默/ 表观遗传调控/ 肿瘤治疗Key words
DNA methylation/ gene silencing/ epigenetic regulation/ cancer therapy分类
医药卫生引用本文复制引用
马爱妞,王永祥,周向军..靶向诱导DNA甲基化与肿瘤治疗研究进展[J].中国临床药理学与治疗学,2009,14(3):241-244,4.
