中国临床药理学与治疗学2009，Vol.14Issue(3)：265-268,4.
益气养阴方对鸡胚尿囊膜移植瘤组织血管内皮生长因子表达的影响
Effect of Yiqiyangyin Fang on vascular endothelial growth factor expression in tumor cells transplanted on chick chorioallantoic membrane
摘要
Abstract
AIM: To study the role of Yiqiyangy-ing Fang on angiogenesis and vascular endothelial growth factor ( VEGF) in tumor cells transplanted on chick chorioallantoic membrane (CAM). METHODS: The chicken CAM model with tumor cells transplanted was adopted. The drug-contained serum was prepared using serum pharmacological method. The effect of CAM angiogenesis induced by tumor cells was observed in serum containing drugs and normal sodium serum as control group. The expression of VEGF in tumor cells transplanted on CAM was investigated by immunohisto-chemical analytics methods. RESULTS: The rat blood serum containing Yiqiyangying Fang inhibited angio-genesis in chicken CAM induced by tumor cells transplanted . The expression of VEGF in Yiqiyangying Fang group was lower than that in control group, there was statistical difference (P < 0.05). CONCLUSION: Yiqiyangying Fang has significant inhibitory effects on angiogenesis induced by tumor cells in CAM. The down-regulation of VEGF expressions may be one of its mechanisms for inhibiting tumor angiogenesis.关键词
益气养阴方/ 血管内皮生长因子/ 血管生成Key words
Yiqiyangyin Fang/ vascular endothelial growth factor/ angiogenesis分类
医药卫生引用本文复制引用
孙静..益气养阴方对鸡胚尿囊膜移植瘤组织血管内皮生长因子表达的影响[J].中国临床药理学与治疗学,2009,14(3):265-268,4.基金项目
山东高等学校优秀青年教师国内访问学者项目资助(2005-115) （2005-115）
