中国临床药理学与治疗学2009，Vol.14Issue(3)：300-306,7.
中国2型糖尿病人中CYP2C8、CYP2C9基因多态性
Genetic polymorphisms of CYP2 C8 and CYP2 C9 in Chinese type 2 diabetes mellitus
摘要
Abstract
AIM: To identify the frequencies and distributive characteristics of CYP2C8 and CYP2C9 in Chinese type 2 diabete mellitus. METHODS: The functional allele CYP2C8~ * 3, CYP2C8P404A, CYP2C9~* 3 were detected by PCR-RFLP and DHPLC methods in 222 T2DM patients. The CYP2C8IVS 2 (-5 insert t) whose function remains unclear was also detected . The frequency of all these alleles were calculat-ed. RESULTS: The alleles of CYP2C8~* 3 and P404A were not found in 222 T2DM patients. The allelic frequency of CYP2C8IVS2 (-5insert t) and CYP2C9~* 3 were 43 % and 2.48 % , respectively. There was no significant difference between the male and female on CYP2C8 IVS2 (-5insert t) and CYP2C9~* 3 alleles.The allelic frequency of CYP2C8IVS2 (-5insert t) combined with CYP2C9~* 1~* 3 was 6.3% . There was no significant difference between the male and female on it, too. CONCLUSION: The frequency of CYP2C9~* 3 was 2.48% in Chinese T2DM patients. The alleles of CYP2C8~* 3 and P404 were not found. The incidence of CYP2C8IVS2 (-5insert t) mutant was 43 .0% , and whether it has influences on CYP2C8 metabolism activity needs further study.关键词
CYP2C8/ 2型糖尿病/ 基因多态性/ 多聚酶链反应-限制性长度多态性法/ 变性高效液相色谱法Key words
CYP2C8/ type 2 diabetes mellitus/ genetic polymorphism/ PCR-RFLP/DHPLC分类
医药卫生引用本文复制引用
何君,周巍,王练词,何婷晔,王丹,范岚,张伟,周宏灏..中国2型糖尿病人中CYP2C8、CYP2C9基因多态性[J].中国临床药理学与治疗学,2009,14(3):300-306,7.基金项目
国家自然科学基金项目(30801421) （30801421）
教育部青年教师基金项目(20070533002) （20070533002）
